Gene First Linked To Rare Disease May Trigger Skin Cancer, Other Tumors
A gene first identified in connection with a rare disease in which patients develop multiple, benign skin tumors may be a more general player in cancers found throughout the body, according to a report in the May 19, 2006 Cell.
The disease familial cylindromatosis results from the loss of a gene called CYLD, causing tumors known as cylindromas to develop in hair-follicle cells. Earlier studies indicated a role for CYLD in inflammation, but the mechanism behind the gene's control over tumor growth had remained uncertain.
A team led by Reinhard F