Combination Therapy Promising for Melanoma Treatment

Armen Hareyan's picture

Recent research by the National Cancer Institute says that more women are being diagnosed with the most dangerous form of skin cancer melanoma. Too much sun exposure and lack of safe sunscreens contribute extensively in the sharp increase of Melanoma. While everyone is recommended to have reasonable amount of sun exposure (here you need to consult your doctor because sun exposure is needed for Vitamin D as well) it's important that you share this news with family and friends about being cautious from the risk of melanoma. We now look at the latest study from UPMC on how combination therapy is safe and promising for melanoma treatment.

The combination of two different biotherapies may be beneficial for patients with inoperable melanoma, according to a University of Pittsburgh Cancer Institute (UPCI) study presented at the 44th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

Researchers in the melanoma and skin cancer program at UPCI combined two biotherapies – treatments that stimulate the immune system to fight cancer – and found the results promising in terms of anti-tumor effects and tolerable in terms of toxicity. High-dose interferon alfa-2b, a standard treatment for metastatic skin cancer, and tremelimumab, an antibody thought to instigate the body’s immune system to attack tumors, were combined for the first time in this phase 2 clinical trial.


“With each new study, we learn something important about melanoma,” said John M. Kirkwood, M.D., leader of the program and professor and vice chairman for clinical research in the Department of Medicine, University of Pittsburgh School of Medicine. “With this study, we learned that adding tremelimumab to traditional treatment is not only safe, but an effective way to induce an anti-tumor response, which is very exciting.”

For this study, 16 patients diagnosed with stage 4 melanoma, all of whom received and had not benefited from at least one round of previous therapy, were given the combination treatment. The overall response rate was 19 percent, and the study has since moved into the second stage, where it will enroll 21 additional patients.

Melanoma is a rare form of skin cancer, but it causes the majority of skin cancer-related deaths. Each year, approximately 160,000 new cases are diagnosed worldwide, and currently surgery is the only effective cure. For patients with inoperable disease, like those enrolled in this study, discovering a safe and effective treatment is vital.
Ahmad Tarhini, M.D., assistant professor at the University of Pittsburgh School of Medicine and lead author of this study, will give the accompanying oral presentation at 10:15 a.m., June 1. Other investigators include S.S. Moschos, M.D.; J.J. Schelsselman, Ph.D.; J. Shipe-Spotloe, P.A.; M. Denmark, all of UPCI.

The Melanoma therapy study is published as abstract number 9009 in the 2008 ASCO Annual Meeting Proceedings.