One Of The Most Common Drugs In The World May Be Causing Male Infertility
Studies claim that Ibuprofen alters the production of hormones and has a negative effect on male reproductive organs.
It started with an investigation by the National Institute of Health and Medical Research of France (INSERM) and now, studies from the University of Copenhagen are supporting the same conclusion. Both studies claim that abuse of ibuprofen is directly correlated with male infertility. The drug, for which no prescription is needed, is one of the most widely used in the world.
Researchers at the University of Copenhagen in Denmark, reported that consuming 600 milligrams of ibuprofen per day for two weeks reduces up to 50 percent of reproductive capacity in males.
"Ibuprofen can alter the production of hormones and have a very negative impact on the testicles," explained David Mobjerg Kristensen, one of the authors of the study, which had 31 athlete participants between the ages of 18 and 35, who frequently consumed anti-inflammatory drugs.
Half of the study participants took a moderate dose of Ibuprofen (600 milligrams or one pill), while the other half consumed a placebo. After two weeks of treatment, it was proved that the body of the men who took the medication instead of the placebo, increased the creation of "luteinizing hormones", which regulate the production of testosterone.
Thus, the study concluded that ibuprofen had impaired the proper functioning of the testicles. The researchers also stated that "continuously ingesting these drugs decreases the creation of testosterone, and therefore reduces fertility by up to 50 percent."
The gynecologist and specialist in reproductive medicine of IVI Buenos Aires, Tania Mielnikowicz, who consulted on the risks of self-medication, said that "the greater the consumption, the greater the number of adverse effects".
"The maximum recommended dose would be up to 1,200 milligrams per day, but with higher consumption, a greater occurrence of adverse effects. In addition, it is very common for ibuprofen to be taken along with other medications, so these effects may be greater, especially if there is no proper medical attention," she went on to explain.
The Danish study also showed that the frequent use of ibuprofen "affects cells that are in the testicles and would decrease a hormone called 'Antimulleriana' from 9 to 7 percent after daily consumption of 600 milligrams at two and six weeks. "
Consulted on the possibility of recovering fertility if the consumption of that medicine is abandoned, Mielnikowicz explained that "having ingested it for a short time in the case of the study, the effects are reversible ".
"It is unknown if the health effects of the use of ibuprofen in the long term or with abuse of years, something that may be common in athletes, could be irreversible, although all daily consumption of a drug will have its consequence," she said.
"As we are talking about medications that are not toxic to the testicles in man or the ovaries in women, it could be suggested that the use of ibuprofen be stopped if the patient wants to be a father or is about to undergo an assisted reproduction treatment."
Regarding the intake of this drug in women, the gynecologist said that "especially in pregnant women, when common analgesics such as aspirin, ibuprofen or paracetamol are taken, an anti-androgenic effect is generated that could interrupt the production of male hormones. "
"It is also shown that paracetamol can also cause damage to the fetuses' testes, so it is always recommended that pregnant or lactating women consult a doctor before using a medication," concluded Mielnikowicz.