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Dr. Julian Lieb presents a simple and highly cost-effective medical solution for infectious disorders and cancer treatment.

Immunostimulation holds the key to HIV/AIDS, countless other infectious disorders, and to cancer. The belief that compounds that stimulate immune function do not exist, and may even be beyond our reach, is a self-serving fiction imposed on society by countless vested interests.

Based on clinical observation, and comprehensive searches of the medical literature, I would favor antidepressants in HIV, AIDS, tuberculosis, and malaria, lithium as an antibiotic in hospital- acquired infections and methicillin-resistant staphylococcal infections.

There are more than fifty published laboratory experiments showing that antidepressants kill cancer cells, inhibit their proliferation, convert multidrug resistant cells to sensitive, protect nonmalignant cells from ionizing radiation and chemotherapy toxicity, and target the mitochondria of cancer cells while sparing those of healthy ones.

There is clinical and laboratory evidence that antidepressants have considerable potential in such treatment resistant malignancies as gliomas, neuroblastomas, hepatomas, and small and large cell cancers of the lungs.

Similar evidence for other malignancies entities is sure to follow. With various cancers emerging as a significant problem in relatively young people with AIDS, the immunostimulating, antimicrobial and anticancer properties of antidepressants offer vast humanitarian and economic benefits. Those wishing to explore the pharmacology of antidepressants with reference to AIDS and cancer should consult my articles, or do their own searching on Medline and Pubmed.

Lieb, J. “Immunopotentiation and inhibition of herpes virus activation during therapy with lithium carbonate. Med Hypoth 1981; 7:885-890

Lieb J. “Remission of herpes virus infection and immunopotentiation with lithium carbonate: Inhibition of prostaglandin E1 synthesis by lithium may explain its antiviral, immunopotentiating, and antimanic properties.” Proceedings of the Third World Congress of Biological Psychiatry, Stockholm. Biol Psych Perris C, Struwe G, Jansson B. (eds.) 1981 695-698

Horrobin D, Lieb J. “A biochemical basis for the actions of lithium on behavior and on immunity: relapsing and remitting disorders of inflammation and immunity such as multiple sclerosis or recurrent herpes as manic-depression of the immune system.” Med Hypoth 1981; 7:891-905

Lieb J. “Remission of rheumatoid arthritis and other disorders of immunity in patients taking monoamine oxidase inhibitors.” Int J Immunopharmac 1983; 5(4): 353-357

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Lieb J. “Lithium and immune function.” Med Hypoth 1987; 23:73-93

Lieb J. “Invisible antivirals.” Int J Immunopharm 1994; 16:1,1-5

Lieb, J. “Lithium and antidepressants: inhibiting eicosanoids, stimulating immunity, and defeating microorganisms.” Medical Hypotheses (2002) 59(4), 429-432

Lieb, J. “The immunostimulating and antimicrobial properties of lithium and antidepressants.” Journal of Infection (2004) 49(2) 88-93

Lieb, J “Lithium and antidepressants: Stimulating immune function and preventing and reversing infection.” Medical Hypotheses (2007) 69, 8-11

CANCER

Lieb, J. “Antidepressants, eicosanoids and the prevention and treatment of cancer.” Plefa (2001) 65(5&6), 233-239

Lieb, J. “Antidepressants, prostaglandins and the prevention and treatment of cancer.” Medical Hypotheses (2007) 684-689

Lieb, J.”The multifaceted value of antidepressants in cancer therapeutics.” Editorial comment. European Journal of Cancer 44 (2) 2008 172-174

Lieb, J.”Defeating cancer with antidepressants.” ecancermedicalscience DOI.10.3332/eCMS.LTR.49

Lieb, J.”The remarkable anticancer properties of antidepressants.” DOI.10.3332/eCMS.LTR.149

About the author: Dr. Julian Lieb has been the Associate Clinical Professor of Psychiatry, Yale University School of Medicine, 1979-1985.

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