The Solution To Health Reform Is At The Molecular Level
In 1930 Rafael Kurzrok and Charles Lieb noted that semen can, paradoxically, cause uterine muscle to either relax or contract. In 1936, Ulf von Euler and Maurice Goldblatt isolated the active principles from the semen of boars, von Euler naming them "prostaglandins" out of the mistaken belief that they are manufactured exclusively by the prostate. In 1960 Sunne Bergstrom characterized the structure of prostaglandins, Bengt Samuelson their metabolic pathways, and in 1971 John Vane showed that aspirin inhibits them, a discovery that stimulated worldwide interest. In 1982, Vane shared the Nobel Prize in physiology and medicine with Bergstrom and Samuelson.
Prostaglandins are ephemeral, infinitesimal, and powerful molecules regulating the physiology of every cell, when up regulated, physiology becomes pathology. They are composed primarily of carbon, oxygen, and hydrogen, and have a configuration resembling a hairpin. Prostaglandins are synthesized, among others, by coral, algae, sponges, fungi, shellfish, fish, insects, reptiles, birds, vertebrates, mammals, primates and humans. Enter, "prostaglandins" in a biomedical database, and you will find tens of thousands of studies revealing their regulation of our physiology. If there is a physiological process not regulated by prostaglandins, it is yet to be identified. In 1982, Erik Anggard referred to prostaglandins as “a generalized, physiological control mechanism.”Databases contain copious evidence of the role of prostaglandins in many of our diseases. They are key factors in food intolerance and hay fever; as much as they are they are in depression, infectious disorders, Alzheimer’s disease heart attacks, strokes, and cancer.
In 1977, David Horrobin showed that prostaglandins regulate nucleic acids (DNA and RNA). Subsequently, others showed that prostaglandins regulate the synthesis, inhibition, and expression of genes, and the growth, differentiation, and replication of cells. By 1990, prostaglandins, and not genes, owned cancer, scientifically, but not politically or commercially. In the nineteen-seventies-and-eighties, prostaglandins attracted substantial drug company investment, Upjohn referring to them as “Medicine’s New Frontier.” With new technology that accelerates the production of DNA, venture capitalists, and the U.S patent office, medical schools and the media launched biotechnology and genomics, stampeding Upjohn into divesting from prostaglandins into buying up biotechnology companies to acquire their patents.
The premier medical journals have paid little attention to prostaglandins, publishing countless articles in which they are not mentioned. You will rarely see prostaglandins mentioned in the major print media. Medical school deans vie for funding, with prostaglandins last on the list, rather than first. Prostaglandins are biomedicine’s standard, with which to differentiate truth from untruth.
Prostaglandins determine tolerance or intolerance towards everything with which the body comes into contact, including stem and genetically altered cells. Medical research is largely based on the premise that DNA and RNA in the cell nucleus, and enzymes and proteins in the cell, whose structures are defined by DNA, are of overwhelming importance in disease. While significant, their practical importance has been exaggerated. Membrane lipids, which modulate the behavior of these entities, offer far more opportunities for practical therapeutic interventions.
Innovations, based on prostaglandins, for infectious disorders, cancer, and cardiovascular disorder that could radically improve the quality of care, and significantly reduce the cost, have been available for a long time, but suppressed by vested interests In “Against Method” Paul Feyerabend noted that suppressing a paradigm in preference to one politically favored could permanently damage society. He cautioned that the guardians of paradigm failures seldom concede to valid newcomers, to the extent that political intervention might hold the only hope of progress. We are amazed at how easily people lost their minds in signing up for the South Seas bubble and the Dutch tulip mania. Posterity may view us as losing ours by neglecting prostaglandins.
Julian Lieb, M.D was a Yale medical school psychiatrist, before switching to the immunopharmacology of infectious disorders and cancer. He is an authority on the role of prostaglandins in depression, infectious disorders, and cancer. Dr Lieb has authored or coauthored forty five articles and nine books.