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Gene Variation Linked To Colon Cancer

Armen Hareyan's picture

A new genetic component is linked to colorectal cancer risk. The gene is related to hormone adiponectin and is found to significantly decrease the colon cancer risk.

A team of researchers from University of Alabama at Birmingham examined 1500 people involving New Yorkers of Ashkenazi Jewish ancestry and Chicago residents. Ashkenazi Jews, coming from Europe are known to be more likely to suffer colorectal cancer. These patients with the newly found gene variation were 28% less likely to develop the colon cancer than those without the gene, while Chicago residents with the gene were at 52% lower risk.

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The hormone adiponectin is secreted from fat cells. Overweight and obese people are known to have less adiponectin secreted and they are definitely at higher risk for suffering from cancers. The mechanism linking hormone existence to overall health is the following: high adiponectin levels in blood are able to suppress blood vessels inflammation, this leads to increased metabolism.

Therefore, higher adiponectin levels decrease the risk of obesity, diabetes, heart disease, breast cancer and now it is also linked to colorectal cancer. It is clear that hormone adiponectin makes people healthier, but how exactly the hormone is being secreted from fat cells is yet unclear.

According to American Cancer Society statistics, colorectal cancer affects 1.2 million and kills 630000 people worldwide each year. This year is estimated to have 149000 newly diagnosed and 50000 cases in US. About 1/3 of cases are associated with family history, other factors causing the disease are believed to be diet reach in fat, calories and low in fiber; drinking habits, smoking, obesity, and unhealthy lifestyle. There are several other genetic components linked to the disease, but adiponectin was never mentioned among them.