Colon Cancer Symptoms and Treatment

Genomic Signature Of Colon Cancer May Individualize Treatment

ruzik_tuzik — Tue, 25 Nov 2008 22:16:43 -0600

Researchers in the Duke Institute for Genome Sciences & Policy have developed a model for predicting risk of recurrence in early stage colon cancer patients, and have used the model to also predict sensitivity to chemotherapy and targeted therapy regimens.

Identifying New Colorectal Cancer Genes

ruzik_tuzik — Fri, 21 Nov 2008 10:38:48 -0600

Researchers from Ottawa and Toronto played a key role in an international team that identified four new genes for colorectal cancer. The discovery, published online in Nature Genetics examined 38,710 genetic markers in 13,315 individuals from four countries. A total of 10 genes have now been linked to colorectal cancer, and together these genes could predict up to a six fold increase in the lifetime risk of developing colorectal cancer.

Cost Of Treating Colorectal Cancer Vary

ruzik_tuzik — Fri, 07 Nov 2008 23:46:08 -0600

The cost of treating colorectal cancer varies widely, with newer, life-extending therapies sometimes costing tens of thousands of dollars more than older agents, according to a study led by a team of researchers in the Duke Comprehensive Cancer Center.

Novel marker of colon cancer

hareyan — Thu, 23 Oct 2008 12:32:16 -0500

Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide. Until now, several molecules have been reported to play an important role in gastroenterological tumorigenesis and tumor metastasis, but the molecular mechanisms involved tumor development and progression still remain unclear in colon cancer.

Several Methods Equally Effective For Colorectal Cancer Screening

ruzik_tuzik — Fri, 10 Oct 2008 09:17:24 -0500

In a change from its previous recommendation, the U.S. Preventive Services Task Force now recommends that adults age 50 to 75 be screened for colorectal cancer using annual high-sensitivity fecal occult blood testing, sigmoidoscopy every five years with fecal occult testing between sigmoidoscopic exams, or colonoscopy every 10 years. According to the Task Force, good evidence exists that using these methods save lives. The recommendation and the accompanying summary of evidence is posted in the Annals of Internal Medicine online at www.annals.org and will appear in the Nov.

Gene Variation Linked To Colon Cancer

hareyan — Thu, 02 Oct 2008 04:02:29 -0500

A new genetic component is linked to colorectal cancer risk. The gene is related to hormone adiponectin and is found to significantly decrease the colon cancer risk.

Screening for Colon Cancer: Just do it

Toni Brayer MD — Wed, 24 Sep 2008 12:44:41 -0500

I have a patient who is absolutely phobic about getting a colonoscopy for colon cancer screening. She has a family history of colon cancer so the fear may be about what is "found" or it may just be the anxiety of going through the test. No amount of cajoling on my part or her husbands part has been successful for getting her tested. I've even offered valium to get her through it but she just won't take that next step.

I feel so strongly about this because colon cancer is one disease that is truly preventable if found early.

Here are some facts:

Trial Compares Accuracy For Virtual Colonoscopy, Standard Colonoscopy

ruzik_tuzik — Sat, 20 Sep 2008 07:01:29 -0500

Computerized tomographic (CT) colonography, also known as virtual colonoscopy, is comparable to standard colonoscopy, which uses a long, flexible tube with a camera to view the lining of the colon, in its ability to accurately detect cancer and precancerous polyps and could serve as an initial screening exam for colorectal cancer, according to the results of the American College of Radiology Imaging Network (ACRIN) National CT Colonography Trial.

What is sign for progressive of colorectal carcinoma?

hareyan — Fri, 19 Sep 2008 12:55:48 -0500

The process of tumor invasion and metastasis is associated with alterations in the functions of several adhesion molecules. In general, tumor cells lose their capacity for normal adherence, which facilitates their detachment from their site of origin. alpha-catenin links E-cadherin to the actin cytoskeleton via its association with either beta- or gamma-catenin. Reduced alpha-catenin expression was associated with tumor invasion and metastases in colorectal cancer (CRC).

Researchers Identify Cancer-Causing Gene In Many Colon Cancers

ruzik_tuzik — Tue, 16 Sep 2008 11:24:58 -0500

Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer.