While molecular biologists and news reporters present jaw-dropping evidence that a red wine molecule called resveratrol may usher in the advent of anti-aging pills, other researchers report that a matrix of small natural molecules, such as those in Longevinex, exert far greater effects than resveratrol alone. For example, a recently reported human study found the Longevinex dietary supplement is superior to green tea.
And while Barbara Walters (ABC News) interviews senior Americans who are living vibrantly active lives beyond the age of 100, she also interviews experts who now say small molecules that can influence the genetic machinery within living cells, concentrated in pill form, may make it possible for Americans to live 150 healthy years on a regular basis.
An optimal matrix for nutraceuticals would provide molecules found in grapes, sesame seeds, onions and apple peels which appear to work additively and synergistically, even exerting a greater effect upon the human genome than plain resveratrol.
While many of the beneficial effects of these natural molecules appear to be dose dependent, requiring doses that exceed those found in foods, there may be diminishing returns when supra-high doses of these molecules are employed.
For example, one study shows that extreme doses resveratrol may impair the uptake of folic acid (vitamin B9) by intestinal cells. Folic acid is an essential nutrient required for repair of DNA gene strands and is utilized by the body to limit the amount of an undesirable blood protein called homocysteine.
Optimal health benefits appear to be achieved when consuming an array of polyphenolic molecules in the range of (100-200 milligrams), as provided in 2-3 glasses of aged red wine, or in well-designed nutraceuticals like Longevinex, which contain no alcohol. Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.