Severe Acne Treatment Drug Warning
Since the drug's introduction in the early 1980s there have been controversial reports of depression and suicidal behaviour that may have occurred in some people taking Roaccutane.
This has led to the drug's manufacturers, Roche, including a warning in the product information that taking the medication may cause depression, psychosis and suicidal behaviour.
However, the chemical mechanism by which this might happen has never been established.
In new independent research, scientists at the universities of Bath and Texas at Austin gave Roaccutane to mice over a period of six weeks, and then monitored the rodents' behaviour.
They found that whilst there was no change in the physical abilities of the mice, the rodents spent significantly more time immobile in a range of laboratory assessments designed to test their stress responsiveness