Overeating, Weight Gain May Promote Breast Tumor Growth
Obesity is a risk factor for the development of many types of cancer, including breast cancer. A new study again associates the risk of extra weight with cancer and adds that women may be able to reduce this risk by taking measures to lose weight before menopause hits.
Paul S. MacLean PhD, an associate professor of medicine at the University of Colorado’s Anschutz Health and Wellness Center, and colleagues studied the effects of overeating and obesity on laboratory rats that had surgery to remove their ovaries, thus mimicking menopause. The found that excess weight plus continued overfeeding promoted aggressive tumor growth and progression of cancer.
One reason for the enhanced tumor growth, the scientists found, was that the obese rats were unable to appropriately handle the excess glucose calories which were then taken up by the cancerous breast tissue. The lean rats, on the other hand, stored the excess glucose and fat in the liver, fat and muscle tissues, and in healthy breast tissue.
The tumors in the obese rats also had higher expressions of the progesterone receptor (PR) which was related to higher expressions of genes involved in energy use and proliferation (uncontrolled growth). This pattern of gene expression is often seen in postmenopausal women with PR-positive breast tumors. Obese women with a positive hormone receptor status have been found to have a poorer prognosis than their leaner counterparts.
"Obese postmenopausal women have increased risk for breast cancer and poorer clinical outcomes compared with postmenopausal women who are lean," said Dr. MacLean. "If our findings in rats translate to humans, it means that the perimenopausal period is a critical window of time for determining breast cancer risk later in life."
Thus, “an obese woman's risk for postmenopausal breast cancer and poor clinical outcome could be reduced by perimenopausal lifestyle modifications, such as restricting food consumption and increasing exercise, and/or perimenopausal use of drugs, such as metformin, to improve metabolic control," the authors conclude.