Gene Found to Explain Why Boys Have Autism More than Girls
For every female that has classic autism there are four males. When including the entire spectrum of autism disorders, boys are diagnosed 10 times more often than girls. Researchers from George Washington University an found a gene that is affected by the sex hormones, which may help better explain the gender differences in autism rates.
RORA Gene Function Suppressed by Testosterone
Valerie Hu, a professor of biochemistry and molecular biology, and colleagues at GWU’s School of Medicine and Health Sciences studied a gene implicated in autism called retinoic acid-related orphan receptor-alpha, or RORA. Previous research has found that RORA is important for the development of the cerebellum and that the brains of people with autism expressed less of it than normal.
To test how RORA is affected by hormones, Hu bathed human brain cells expressing the gene in either estradiol, a form of estrogen, or dihydrotestosterone (DHT). They found that estradiol enhanced the expression of the gene where DHT suppressed it, protecting females against RORA deficiency.
The team also found that RORA regulates another gene which controls aromatase, an enzyme which converts testosterone to estrogen. If RORA is under-expressed, aromatase cannot function properly, causing testosterone levels to accumulate in dangerous amounts which are thought to contribute to the development of autism.
"For a long time elevated fetal testosterone has been a proposed as risk factor for autism, but the problem is that there has been no molecular explanation," says Hu. "Now we have evidence for a really exacerbating situation. What we have identified is an inhibitory feedback loop. That is what makes this so fascinating."