Could Diet and Exercise Help Both Depression and Stroke Risk?

2011-08-16 10:48

This month, a new study found that postmenopausal women with a current or past history of depression were at a 29% increased risk of stroke. Thankfully, some simple lifestyle habits – namely diet and exercise – have been found to be beneficial both for the cardiovascular system and in the reduction of depression symptoms.

The study, conducted by Dr. Kathryn M. Rexrode MD of Harvard Medical School, surveyed more than 80,000 women between the ages of 54 and 79 for six years beginning in 2000. At the start of the study, 22.3% of the women self-reported that they were depressed. During the study period, just over 1,000 strokes occurred in the study participants.

Women with a current diagnosis of depression had a 41% greater risk of stroke, while those who reported having a history of depression had a 23% greater risk over women who had never been depressed or had never taken an antidepressant medication.

Depression on its own can influence stroke rate in a variety of ways including neuroendocrine and inflammatory pathways. However, the antidepressant medication also carries risks, including a risk of sudden death and fatal coronary heart disease. The most commonly-taken form of antidepressant (SSRI’s including Prozac and Zoloft) was linked to a 40% increased risk of stroke during the study period.


While the researchers attempted to control for various factors such as age, history of heart attack or other cardiovascular risk factors (such as hypertension), physical activity level, body mass index, alcohol consumption, smoking status, and diet score, many of these factors are significant in the risk of having a stroke. Notably, the majority of the strokes that occurred during the study period were ischemic strokes, the type caused by an obstruction within a blood vessel to the brain (atherosclerosis).


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