Bone Marrow Stem Cells Benefit Patients With Chronic Heart Failure
The European Society of Cardiology has released results from the STAR-heart study at the ESC Congress 2010 meeting taking place this week in Stockholm. The study found that bone marrow stem cell therapy improves ventricular performance, quality of life, and survival in patients with chronic heart failure.
Heart Failure is Only Major Cardiovascular Disorder on the Rise
According to background material provided by the ESC, heart failure is one of the most common reasons for acute hospital admissions and is the only major cardiovascular disorder on the rise. About 30 million people in Europe have heart failure, a progressive condition in which the heart’s muscle becomes weakened after an injury (such as a heart attack or high blood pressure) and gradually loses the ability to pump enough blood to supply the body’s needs.
The STAR-heart study followed 391 patients with chronic heart failure as a result of ischemic heart disease following myocardial infarction (heart attack). Left ventricular ejection fraction (LVEF) - the ability of the heart to pump blood from the left ventricle - was 35% or less. 191 of the patients agreed to intracoronary bone marrow stem cell therapy.
The bone marrow was taken from the top of the pelvic bone, an area called the iliac crest. The cells were infused into the infarct-related artery via an angioplasty balloon catheter. The patients were followed for five years and found to have a significant improvement in LVEF, cardiac index, exercise capacity, oxygen uptake, and LV contractility.