The recent findings on Turmeric’s anti-aging effects
Recent studies have observed in animal and human trials that Turmeric’s natural chemical knows as Curcumin, (the yellow pigment from the rhizoma of Curcuma longa), exerts powerful anti-oxidant, photo-protective and anti - inflammatory activities. This leads scientists to believe that curcumin has anti-ageing effects.
A review of the literature on the effects of Curcumin in the body, published by the journal of alternative medicine, found that a high dose of Curcumin is not toxic for humans. In one of the studies 25 subjects used up to 8000 mg of curcumin per day for 3 months, and five other subjects used 1125-2500 mg of curcumin, which was also found to be safe.
The ageing stressor factors and the three ways Turmeric is anti-geing
There are three main aspects of ageing: oxidative stress, inflammation and sun damage.
Experts at the Deparment of Neuroscience and Neurology in Finland, explain that during aging, adaptive immunity significantly declines, while innate immunity seems to be activated which induces a characteristic pro-inflammatory profile.
The first way in which Turmeric works is by inhibiting the number of different molecules that play a role in inflammation. In 2010 an article published at Current Design, has measured the molecular targets of curcumin in the body. The researchers found that that curcumin directly affects a few major targets, such the NF-κB signaling pathways, which can in turn suppresses the pro-inflammatory state involved in the etiology of ageing and age-related diseases. Therefore, Curcumin’s anti- ageing results are compelling.
The second way Turmeric is anti-ageing is by fighting oxidative stress, because in the same study, Curcumin’s molecules were observed to take another important anti-ageing effect in the body, as its molecules are able to trigger the Nrf2/ARE signaling pathway, which plays a key role in activating antioxidative enzymes, phase 2 enzymes and so - called vitagenes, which have a pivotal role in oxidative stress-induced diseases. It is well known by scientists that anti- oxidants are important in order to fight free radicals, which are cells that have been damaged overtime.
Finally, Curcumin has been proven to be photoprotective (prevents sun damage), by blocking UV rays, which are known to provoke oxidative stress, a mediator of apoptosis (cell death). In an experiment conducted by Department of Bioscience Technology and Center for Nanotechnology, it was proven that Curcumin is able to inhibit UV irradiation-induced cell death. Scientists exposed A431 cells (a model human cell line used for research) to various doses of curcumin. Some were exposed to UV light irradiation, other samples were exposed to UV light irradiation after pre-incubation with Curcumin, and cell viability was determined. Approximately 50% of cells died after 200 J/m2 UV irradiation, and this cell death was reduced by Curcumin in a dose-dependent manner.
Considering all the above facts, it can be concluded that the Curcumin has a lot of potential as a more natural approach to heal and prevent certain diseases that are age related and is a powerful natural anti- ageing spice.