Cholesterol Drug Juxtapid Costs $200K Plus, Has Serious Effects

2012-12-25 14:59

Just in time for Christmas, the Food and Drug Administration (FDA) approved Juxtapid (lomidapide), a new cholesterol drug for individuals who have a rare genetic type of high cholesterol called homozygous familial hypercholesterolemia (HoFH). Juxtapid comes with a hefty price tag of $200K plus per year, and its own black box warning of serious side effects.

Who will benefit from Juxtapid?

Familial hypercholesterolemia (FH) is a genetic condition that is characterized by extremely high levels of total cholesterol and bad cholesterol: low-density lipoprotein (LDL). Two forms of FH exist: homozygous and heterozygous, which is associated with the types of genes that a person inherits and can pass on.

Without delving into the complexities of the genetics, suffice it to say that heterozygous FH occurs in about 1 in every 500 people around the world, while homozygous FH is much rarer, seen in about 1 in every one million people. Therefore, Juxtapid is a drug for a very limited number of individuals.

Children with HoFH are at risk of heart attack or coronary disease as young as one to two years old, so it is critical to effectively lower their LDL cholesterol as much as possible to slow progression of atherosclerosis (plaque accumulation in the blood vessels). According to Medscape, HoFH is associated with severe atherosclerosis that affects all the main arteries, including the carotid (arteries in the neck that supply the head), coronary (two major heart arteries), femoral (provides blood to the thighs, groin, lower abdomen), and iliac (pelvis and lower limbs).

In addition to cholesterol accumulations in the arteries, the substance also gathers under the skin, creating fatty deposits. These deposits may be identified as early as birth, which helps with early diagnosis and treatment of the disease.

Juxtapid for HoFH

According to Aergerion Pharmaceuticals, which makes Juxtapid, yearly treatment with the oral drug will cost $200,000 to $300,000, and along with the high price tag comes a black box warning of serious potential side effects for the liver. Specifically, use of Juxtapid can cause liver toxicity.


Subscribe to EmaxHealth on YouTube


Goes to show you how far the chemical conglomerates have come since their humble beginnings as I.G.Farben, who made millions out of fabricating Zyklon X, the deadly gas used in WW 2 extermination camps. $200 000 per year for a box of dangerous side effects!!!!