Will Oxytocin Nasal Spray Treatments for Autism Really Work?

May 27 2014 - 11:46am
Oxytocin Autism Treatment

About a year ago I first heard of a collaborative study aimed at seeing if an Oxytocin Nasal Spray would work in targeting the “core symptoms” of autism. The very mention of a potentially better treatment method sent this author into full blown excitement. When I started looking more into the treatment I became unusually enthused, as well as somewhat intrigued.

The Studies
Said study was launched in 2013 with help from a $12.6 million dollar grant from the U.S. Government [NIH specifically]. SOARS-B [Study of Oxytocin in Autism to improve Reciprocal Social Behaviors] is based out of:

• The University of North Carolina ASPIRE program, in Chapel Hill and Durham
• The Lurie Center for Autism at Massachusetts General Hospital, Boston
• Seaver Autism Center at Mount Sinai School of Medicine, New York
• Seattle Children’s Research Institute
• The Vanderbilt Treatment and Research Institute for Autism Spectrum Disorders in Nashville.

The study is said to be following 300 autistic children. During which half of the children are given the Oxytocin Nasal Spray and the other half a placebo. This happens for ½ the life of the study. The second ½ of the study all the children are given the Oxytocin Treatment. The results of this study have yet to be published. However I, personally, found how a great deal of these oxytocin studies came to be funded just as interesting as the studies themselves.

Studying the effects of oxytocin on an autistic individual has been a large point of interest for some time now. A great deal of the money being handed out to do these studies is coming from one source, AutismSpeaks. In 2008 AutismSpeaks gave a $378,871 grant to Hebrew University in Jerusalem to look into the effect of oxytocin levels in a mother prior to birth as well as the effects that synthetic oxytocin [Pitocin] on an infant as well as it’s overall correlation to autism. In 2010 AutismSpeaks funded the very first “pilot” Oxytocin Nasal Spray study targeted at following 25 autistic youths for 8 weeks. AutismSpeaks gave the University of North Carolina a grant for $119, 999 to complete this study. This pilot study is what led to the government grant that allowed for the large case study we are all currently waiting on results from. In the years since AutismSpeaks has funded several other studies surrounding the use of Oxytocin, all with seemingly positive results.

One such 2012 Stanford University study proved to be extremely valuable. In this study they were able to make a correlation between Oxytocin and Serotonin levels in the brain. They were also able to effectively show that oxytocin influences the levels of serotonin seen. That oxytocin actually acts much like an antidepressant does. It increased amounts of serotonin present in the brain.

The Stanford team was also able to show that oxytocin increased serotonin levels specifically in the brain’s nucleus accumbens. This led them to the conclusion that the relations between oxytocin and serotonin could be fundamental in making social interactions enjoyable for an autistic individual.



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I'm a 67-year-old with high functioning autism. I began experimenting with oxytocin nasal spray about two years ago, mixing my own solutions at home (certainly not those silly oxytocin "trust" sprays peddled on the Internet). At first, I was absolutely amazed at the results. To me, it was like a miracle, I felt I could finally relate to others in a "human," relaxed and completely natural way. Nowadays, I don't use it so much and the effect is seemingly not so profound. I can only speculate as to the reasons why. Does one build up a tolerance level? Perhaps I "jump-started" my own natural oxytocin production? Perhaps it accelerated my social learning curve? Maybe I reached a plateau of sorts, following which came diminishing returns? I'm not saying that oxytocin would be good for anyone and everyone on the spectrum, but this should certainly be explored, I think it could work wonders for many.