Probiotics trump antiobiotics in preventing infections
Medical professionals and scientists are scrambling to find answers to the growing crisis of superbugs and hospital-acquired infections. And according to materials released March 12, 2014, Caltech researchers suggest they may have found a viable and cost-effective answer – probiotics.
Through extensive research scientists are beginning to understand the far-reaching benefits of a healthy population of gut microbes, including reducing systemic inflammation, supporting digestion, relieving inflammatory bowel diseases, aiding the immune system and influencing behavioral disorders. Consumers are also becoming more aware of these benefits increasing their demand.
Caltech professor of biology and biological engineering Sarkis Mazmanian and his colleagues investigated the effect of gut microbe balance on immunity among mice. What the researchers found was that mice born without gut bacteria (germ-free mice) had fewer immune cells – specifically macrophages, monocytes and neutrophils – than healthy mice with a normal amount of gut microbes.
The germ-free mice also had fewer granulocyte and monocyte progenitor cells, which differentiate into mature immune cells, like macrophages, neutrophils and monocytes. In addition, those progenitor cells that the germ-free mice had were defective.
Upon discovering this defect in immune cell production among germ-free mice, the study authors further investigated if germ-free mice would be able to fight infections as well as their healthy counterparts.
The researchers exposed both healthy and germ-free mice to the harmful bacterium Listeria monocytogenes – the bacterium responsible for a serious infection resulting in fever, stiff neck, confusion, weakness vomiting and diarrhea in humans.