Memory loss may be early sign of dementia - 10 warning signs to look for

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2013-07-18 12:16

Many Baby Boomers joke about having a “senior moment”, often dismissing brief memory lapses as a normal part of the aging process. However, if you forget more than someone’s name or find yourself increasingly misplacing your car keys, it could be an early sign of Alzheimer’s disease, according to new studies from several research teams.

Even doctors frequently dismiss a patient’s complaint about memory loss as the “worried well”, but the new studies show they may well have reason to worry, said Maria Carrillo, a senior scientist at the Alzheimer's Association.

In one such study, participants who initially reported memory changes then progressed to broader mental decline six years later. Another study confirmed that dementia was setting in, as evidenced by changes on brain scans.

"Maybe these people know something about themselves (that their doctors don't), and maybe we should pay attention to them," said Dorene Rentz, a psychologist at Massachusetts General Hospital who was involved in one of the studies presented Wednesday at the Alzheimer's Association International Conference in Boston.

In a significant shift highlighted at the conference, leading Alzheimer’s researchers identified a new category called “subjective cognitive decline,” which refers to an individual’s own sense that their memory and cognitive skills are getting worse even when no one else notices.

“The whole field now is moving to this area, and saying ‘Hey, maybe there is something to this, and maybe we should pay attention to these people,’ ” said Dr. Ronald C. Petersen, chairman of the advisory panel to the federal government’s new National Alzheimer’s Project.

Dr. Petersen, who also serves as director of the Mayo Clinic’s Alzheimer’s center, said that preliminary results of a Mayo study of healthy older adults in Minnesota confirmed something similar.

“Lo and behold, those who had a concern about their memory in fact had more likelihood (of later developing mild cognitive impairment, an early phase of dementia),” said Peterson, adding that study participants with memory concerns were 56 percent more likely to be diagnosed with such impairment, even when results were adjusted for factors, such as education, genetic risk and psychiatric issues like anxiety and depression.

“These people are sensing something, and there’s some biological signals that correlate,” Dr. Petersen said. “I think it’s real.”

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