Vitamin D reported to lower the risk of multiple sclerosis
A new study by Swedish researchers has reported that individuals with high levels of Vitamin D in their blood have a lower risk of developing multiple sclerosis (MS). Researchers affiliated with Umeå University, Umeå, Sweden published their findings on November 20 in the journal Neurology.
The goal of the study was to examine the association between Vitamin D (25-hydroxyvitamin D (25[OH]D)) levels and the risk of MS in blood samples collected prospectively and during pregnancy. (Prospective collection means that the samples were collected before the individuals developed MS.) The investigators evaluated 291,500 blood samples from 164,000 individuals collected since 1975 in the northern half of Sweden. They identified prospectively collected blood samples from 192 MS cases matched two to one with controls matched and samples from pregnant mothers whose offspring had later developed MS (37 women, matched five to one with controls. Vitamin D levels were measured using an ELISA, and the risk of MS was analyzed using matched logistic regression.
The researchers found that Vitamin D levels in prospectively collected blood samples were associated with a decreased risk of MS (odds ratio: 0.39). No decrease in MS risk was found in the offspring exposed to higher Vitamin D levels in utero. The prevalence of Vitamin D levels in the control women decreased gradually from 1976 through 2005.
The researchers concluded that their study supports the presence of an association between high Vitamin D levels during the years preceding disease onset and a decreased risk of MS. In the very limited material with samples drawn in early pregnancy, where month-of-birth effects were controlled for, they found no association between gestational Vitamin D levels and MS risk in the offspring. They noted that decreasing Vitamin D levels in the population may contribute to explain the increasing MS incidence that is suggested from epidemiologic studies.