New viral treatment annihilates acne

2012-09-25 10:13

An acne breakout has been the source of embarrassment to countless teens. Many try over-the-counter remedies or consult a physician in an attempt to avoid “ruining their life.” Physicians may soon have a new weapon against acne: a harmless virus living on our skin that naturally seeks out and kills the bacteria that lurk in our pores and cause dreaded zits.

UCLA and University of Pittsburgh researchers published their findings online on September 25 in the American Society for Microbiology’s mBio.

The researchers used drugstore pore-cleaning strips to lift acne bacteria and acne-battling viruses from the noses of pimply and clear-skinned volunteers. When the team sequenced the viruses’ genomes, they uncovered multiple traits ideal for a new therapeutic approach, one that could allow patients to avoid the problem of antibiotic-resistant strains of acne bacteria and the risky side effects of drugs like Accutane.

“Acne affects millions of people, yet we have few treatments that are both safe and effective,” noted principal investigator Dr. Robert Modlin, chief of dermatology and professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. He added, “Harnessing a virus that naturally preys on the bacteria that causes pimples could offer a promising new tool against the physical and emotional scars of severe acne.”

The researchers looked at two little microbes that share a big name: Propionibacterium acnes, a bacterium thriving in our pores that can trigger acne; and P. acnes phages, a family of viruses that live on human skin. The viruses are harmless to humans; however, they are programmed to infect and kill the aforementioned P. acnes bacteria. When P. acnes bacteria aggravate the immune system, it causes the swollen, red bumps associated with acne. Most effective treatments work by reducing the number of P. acnes bacteria on the skin.


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When will it be available? Are there side effects
At present, the researchers are conducting laboratory tests. It us likely that clinical trials may start in the near future. Often, UCLA asks for volunteers for these trials. It is unlikely that the treatment will have any side effects since it is a harmless virus found on the skin. If you need help right now, schedule an appointment with one of the three doctors affiliated with CARA. CARA - Clinic for Acne, Rosacea, and Aesthetics The Clinic for Acne, Rosacea, and Aesthetics (CARA) has been providing outstanding and comprehensive care for acne and rosacea since 2011. This subspecialty clinic within the Division of Dermatology at UCLA Medical Center provides a broad scope of medical, surgical and cosmetic therapies for acne and rosacea in adults, adolescents, and young children. Medical therapy can include topicals and/or pills, and the team takes time to individualize treatment regimens that will best suit the patient’s age and lifestyle. In addition, CARA offers leading-edge aesthetic procedures to improve the appearance of scars, textural changes, and discolorations that acne and rosacea can leave behind. Patients will benefit from the newest techniques offered by UCLA Dermatology, such as lasers, chemical peels, fillers, subcisions, and scar excisions. The dermatologists at CARA are actively involved in basic science and clinical research, thereby contributing to and staying abreast of the latest developments in the field of acne and rosacea. They are also committed to teaching future dermatologists, hence supporting a dynamic interaction among students, residents, and fellows. The following are the dermatologists of CARA: Jenny Kim, MD, PhD Christina Kim, MD Ki-Young Suh, MD