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Grey Matter Loss in Bipolar Disorder Patients

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By Armen Hareyan on August 1, 2007 - 4:28pm for eMaxHealth

People with bipolar disorder - or manic depression - suffer from an accelerated shrinking of their brain, researchers at the University have found.

The study shows for the first time that bipolar disorder - a condition characterised by periods of depression and periods of mania - is associated with a reduction in brain tissue and proves that the changes get progressively worse with each relapse.

The findings, published in the Journal of Biological Psychiatry, show that the loss of grey matter tissue is concentrated in areas of the brain which control memory, face recognition and coordination - namely the hippocampus, fusiform and cerebellum respectively.

Dr Andrew McIntosh, Health Foundation Clinician Scientist and lead researcher, said:

"For the first time, we have shown that as people with bipolar disorder get older, a small amount of tissue is lost in parts of the brain that are associated with memory and the coordination of thoughts and actions.

"The amount of brain tissue that's lost is greater in people with multiple episodes of illness and is associated with a decline in some areas of mental ability.

"Although we do no yet know the cause of this brain shrinkage, it may be that repeated episodes of illness harm the brain and lead to the decline.

"Another possibility is that the brain changes are caused by stress or genetic factors, which tend to lead both to more frequent illness episodes and to greater brain loss. Further research will be required.

"This discovery has implications not only for the way we research the disease, but may also impact the way this condition is treated."

Bipolar disorder, in its severe form, is a serious mental illness which affects around half a million people in the UK alone.

When people have mania they are typically elated, overactive and need less sleep. They may also suffer from delusions or hallucinations, and are at significant risk of suicide.

Once someone has an episode of bipolar disorder, the condition tends to be life long.

This work is supported by the Sackler Foundation, Health Foundation and by the UK Medical Research Council.

Source: 
University of Edinburgh

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Comments

#1 Anxiety and bipolar

Submitted by Anonymous on October 6, 2008 - 8:48pm.

I found out 6 months ago i have probably had bipolar disorder since teen years !
did not now it , just thought i was a happy go luck, smart, and mre energetic than
any one else in the family ?
giving was my talent, so giving away everything at times seemed normal
had a good happy productive 25 years before my first switch to depression
now i am trying to stabelize the Anxiety problem, it started 3 years ago and
Xanax helps it alot, can one stay on Xanax for life if need be with out killing
their liver ??
is there any thing that you CAN NOT TAKE XANAX WITH?
carol ann from Texas

  • reply

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