What researchers discovered about Crohn's disease in the past year

2013-12-31 11:36

Autoimmune diseases like Crohn’s are poorly understood by researchers. Scientists are still uncertain about how the body’s immune system attacks perfectly healthy cells to lead to disease like type 1 diabetes, lupus, Crohn’s disease, multiple sclerosis and more. But 2013 has lead to some advances in understanding Crohn’s disease that can lead to better treatment and improved quality of life for those suffering from the condition that can be debilitating.

Understanding Crohn’s disease with fibrosis

Researchers from University of Bristol uncovered the culprit for scarring and hardening of the intestines that can happen with Crohn’s disease and often requires surgery.

Fibrosis causes the intestines to narrow and become thick so nutrients cannot be absorbed and feces can no longer pass.

In their study, the scientists isolated a protein known as IL-13 that is overly expressed that promotes Crohn’s disease fibrosis. The result of the finding will lead to better therapies for the disease that can be started before fibrosis and the need for surgery occurs. The finding was published in the journal PLoS ONE in December, 2012.

New drug therapy on the horizon for Crohn’s disease?

The drug Vedolizumab is currently under development for treating Crohn’s disease.


Share on Facebook submit to reddit Share on Google+


i look forward to hearing any new information on Crohns. it is such a difficult illness to live with!
Jackie, we feel the same way here at EmaxHealth, which is one of the reasons we have been looking for new research and other treatments. There are diseases that get more focus than others and more funding for research. Of course, finding the cause and knowing how to prevent it completely would be the absolute best! Then for those who have it, an absolute cure. Thank you for your comment.
In reference to the enterovirus, does that mean a virus you have in childhood(like a stomach virus) or does that mean a virus that lives within the intestines of the child?
My husband has been battling chrons/ultra colotits since 2005 he see a GI Dr and was diagnosed with this disease there at first he was getting his meds. Now since we can't afford the dr office fees he won't give him anymore meds. He has to have the steroids if not he will get inflamed he has so much abdominal pain what do we do
Hi Linda - according to the study authors, the intestines seemed to be compromised from either persistent infection or one that keep recurring.
Oh Angela, I am so sorry. If the problem is not getting to the doctor, please consider speaking with their financial (billing) office to work out a payment plan. Most doctor's offices are more than willing to do that. Can you tell me if your husband has health insurance?
This was an interesting read for the most part, however id say that its not new knowledge to say that this disease is very individualistic and its hard to find treatment that works. In regard to pamphlets and such? Most areas have a chapter of the CCFA in their areas and I know from experience that they provide all the informational pamphlets you could hope for. They even had ones directed towards teachers that I gave to each of mine while I was in school for understanding and coping with your student. Someone commented about costs of meds on here and I know how that goes. I can only take one anti-acid and of course its not covered. You can usually go to the drugs website and print out coupons/savings cards. I've done that multpile times and have paid either very little or nothing at all, their pretty great.
Anyone been taking Azathioprine and experienced muscle wasting? Done with that drug!!! Dangerous and doctors treat you like, oh well!!