How fruit flies help researchers understand insulin resistance and diabetes

2012-06-07 08:02

Fruit flies help researchers understand human diseases like Alzheimer’s disease and cancer. Now scientists have developed an insulin resistant fruit fly to help them understand the metabolic underpinnings that are hallmarks of type 2 diabetes. The goal is developing new treatment options for the disease that is linked to obesity and poor diet.

Experiments show how different diets could lead to type 2 diabetes

For their experiments the researchers fed the fruit flies a high nutrient diet to mimic what happens when humans become obese and insulin resistant.

Johannes H. Bauer, principal investigator for the study at Southern Methodist University, Dallas explained in a media release that the new model poses ‘endless possibilities’ for learning how to treat obesity and insulin resistance “…as well as drug treatments for the condition, as well as how to treat obesity, how to block insulin resistance and how metabolic changes from a specific diet develop.”

The researchers wanted to see if different diets led to diabetes. They fed one group a high-carbohydrate diet and the other a diet over-loaded with protein.

In each instance the fruit flies developed insulin resistance, which was a surprise. The scientists expected a high carbohydrate diet to lead to obesity. What they didn’t anticipate was how quickly a high protein diet also led to insulin resistance even though they lost weight with higher levels of dietary protein.

The carbohydrate diet mimicked the effect in humans from eating too many sweets, french fries, pasta and ice cream. The over-loaded protein diet would be similar to the popular Atkins diet.

Carb-loaded flies gain weight. Protein-loaded flies gain and then lose weight. So the two diets have exactly opposite effects on metabolism,” Bauer said. “But too much of either one of them causes insulin resistance. That surprised us.”

Fruit flies given a high carbohydrate diet became less fertile and laid fewer eggs. The high protein diet flies laid more eggs initially, but too much protein had the opposite effect. Both diets shortened lifespan. Both diets induced insulin resistance.

“The carb data imply a linear relationship between carb levels and health. The more carbs, the more weight, the more sugar storage and fat, the more insulin resistance and the less fertility,” Bauer said.


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