Diabetes control: New approach contradicts current views

2011-09-05 18:21

In a new study that challenges how diabetes is controlled, researchers found boosting the activity of proteins activated by inflammation might be beneficial, contradicting current views. Inflammation brought about by obesity is blamed as a major contributor to type 2 diabetes.

In the discovery, researchers describe what they call a “paradigm shift” in our understanding of the mechanism of how type 2 diabetes develops and could be managed.

Inflammation activates two crucial proteins that control blood sugar

In the study, researchers from Children's Hospital Boston report that two proteins activated by inflammation normalized blood sugars in diabetic mice.

The research, led by Umut Ozcan, MD, in the Division of Endocrinology at Children's Hospital, completely contradicts the notion that inflammation is detrimental for controlling diabetes.

Rather, the finding suggests obesity and insulin resistance may destroy the body’s ability to respond to inflammation. Finding ways to boost the inflammatory response could be a new treatment approach.

The research team previously showed that obesity causes endoplasmic reticulum (ER) stress. The endoplasmic reticulum is important for normal cell functioning. ER stress impairs the body’s response to insulin.

Advertisement: Content below.

The scientists also showed a protein called XBP1s, cannot function in obese mice.

Artificially activating the protein in the liver of mice with type 2 diabetes, and also in lean, insulin-deficient type 1 diabetic mice, caused blood sugar levels to return to normal in the mouse studies.

A second protein, called p38 MAPK, which is triggered by inflammation, makes XBP1s more active. Without p38MAPK, XBP1s can’t function to keep blood sugar levels in check.


Subscribe to EmaxHealth on YouTube


I like football, curry and a cold pint on a sunny day. Enjoy tr. My name is connie, i am 67 years young. I wanted a change in my life and recentl. My name is Bethan, I'M looking for friendship or maybe more, i have black hair and brown eyes, i am. Hi, I'M a 24 year old just finishing my MSc. I can be soft, I can be hard. I'M at university studying music and photography. Im a scorpio and i love to d. I am devoted and ready fo.