Anesthesia early in life linked to learning disabilities, ADHD

May 31 2011 - 1:23pm
Anesthesia could lead to brain deficits in children.

Research strongly links anesthesia given to children early in life to brain deficits. According to a Pediatric Anesthesia Neurotoxicity Panel led by Dr. Vesna Jevtovic-Todorovic, M.D., Ph.D., M.B.A., Professor of Anesthesiology and Neuroscience at the University of Virginia Health System, infants and children who undergo procedures requiring anesthesia could experience learning disabilities, memory problems, ADHD and cognitive difficulties.

Animal studies have raised major concerns about anesthetics like ketamine given to infants and children that could affect the developing brain. Studies performed on rhesus monkeys, whose brains are similar to humans, strongly link anesthesia exposure to functional difficulties.

Merle Paule, Ph.D., Director of the Division of Neurotoxicology at the National Center for Toxicological Research and SmartTots Scientific Advisory Board member, says the studies raise serious concerns about repeatedly exposing children to anesthesia. l

One exposure to anesthetic could have long-last effect on the brain

In primate studies, one exposure to ketamine, a type of anesthetic often used in children in the emergency room and for minor procedures, led to long-lasting deficits in animal brains.

The effects of anesthesia on human infants and children could be long-lasting, raising major concerns about multiple exposures to anesthesia before age 2.

Randall Flick, M.D., M.P.H., Associate Professor of Anesthesiology and Pediatrics at the Mayo Clinic said, "Very clearly, the studies done by the folks at the National Center for Toxicological Research are extremely important. They can't be overrated because they show in a species similar to humans that there is an effect not only on the pathology in the brain, but also in behavior.”

The findings were presented during the SmartTots: Pediatric Anesthesia Neurotoxicity panel at the International Anesthesia Research Society annual meeting in Vancouver, B.C.

Dr. Flick also discussed Mayo Clinic research at the meeting which concluded multiple episodes of anesthesia exposure before age 2 is a “significant” risk factor for Attention Deficit Hyperactivity Disorder, even after adjusting for illness that might contribute to cognitive function difficulties in children.

He notes, one exposure to anesthesia did not seem to increase the chances of ADHD or learning disabilities. However, age of exposure and number of anesthetics an infant or child is exposed to seemed to be “crucial”.

Children undergoing anesthesia before age 4, longer than 120 minutes, seem to have twice the risk of developing Attention Deficit Hyperactivity Disorder.

Anesthesia effects on young brains may be reversible

The good news is multiple exposures to anesthetics that can lead to learning disabilities and ADHD later in life are reversible, say researchers.The effect of an inhaled general anesthetic agent, sevoflurane was reversible in rats. Scientists used environmental enrichment within 3 weeks of exposure to the drug.

The finding was discussed at the meeting by Greg Stratmann, M.D., Ph.D., Associate Professor of Clinical Anesthesia and Perioperative Care at the University of California, San Francisco. According to Stratmann, “These findings support the concept that harnessing the brain’s natural ability to adapt to functional demands can modify the course of anesthesia-induced cognitive decline in rats.”

Studies pose dilemma for parents, physicians

The studies pose dilemmas for parents and physicians concerned about the effect of anesthesia on infants and children who need surgery that requires anesthesia but can have a detrimental effect on the developing brain.



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