Melantonin May Be A Successful Uveitis Treatment

2008-11-23 09:02

Uveitis is a sudden inflammation of the eye that can cause blindness in 10 to 15% of cases. Research now suggests that melatonin can successfully treat the inflammatory changes that occur with uveitis, and protect the eye from damage. The findings on melantonin and Uveitis treatment appear in the December 2008 issue of The American Journal of Pathology.

Uveitis can be caused by several factors. The uvea is an important structure, as it supplies most of the blood to retina of the eye. It lies between the sclera and retina. Uveitis most commonly occurs in the front part of the eye. The condition is associated with rheumatoid arthritis but can result following exposure to toxins or as the result of eye injury. Other autoimmune diseases can also cause uveitis, such as multiple sclerosis, Grave's disease and systemic lupus erythematosis. HIV, herpes, sarcoidosis, toxoplasmosis and ulcerative colitis have also been associated with uveitis.

A common treatment is steroids, which can have unwanted side effects. Steroids that have to be used long-term can cause glaucoma. Middle age and young people are most commonly affected. There might be no underlying disorder. Uveitis might affect only one eye.

If uveitis occurs in the back of the eye, it can cause scarring that leads to blindness. Systemic infections can induce posterior uveitis, a condition known as chorioiditis. If the retina is also involved, the condition is called chorioretinitis.


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If a an adult with uveitis wanted to take melatonin to help uveitis, what would the daily dose be? Thanks!
Hi, Thanks for your inquiry. There are no current recommendations for treatment in humans, so the dose has not been established. The research was successful for animals so far. I think it would be reasonable to speak with your opthamologist about the study. Your family doctor should also approve any supplements.