Black Seed Oil Compound Kills Prostate Cancer Cells in Lab Study

2010-06-02 22:29

Black seed oil from the Nigella sativa plant is found to kill prostate cancer cells, found in lab studies. Researchers from Tulane University have shown that Thymoquinone (TQ) has anti-cancer properties that suppress the growth and lead to death of aggressive prostate cancer cells. The discovery comes from the scientists desire to find natural compounds with anti-cancer properties.

According to Dr. Debasis Mondal who was part of the research team, “Complementary and alternative medicine (CAM) is becoming very important as an adjunct therapy in cancer patients, both to ameliorate the side effects of chemotherapy as well as to enhance their anti-tumor effects. The low side effect profiles of natural compounds is also an important aspect in their therapeutic utility as an adjunct to anti-tumor therapy.”

The researchers recognized that Thymoquinone in black seed oil (Nigella sativa) has a similar effect to the compound ubiquinone or co-enzyme Q that is also an essential nutrient produced by the body. They found that Thymoquinone rapidly generates reactive oxygen species (ROS) in particularly aggressive types of LNCaP and C4-2B prostate cancer cells. Cancer cells that are resistant to chemotherapy are found to have high levels of glutathione (GSH) that also decreased with exposure to the black seed oil compound.

The research suggests it is the combined action of ROS induction and inhibition of glutathione levels from Thymoquinone found in black seed oil that leads to death of prostate cancer cells. Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine says the researchers… “have demonstrated that Thymoquinone efficiently killed hormone-dependent and hormone-independent prostate cancer cells. The mechanism appears to be that Thymoquinone induces oxidative stress and suppresses GSH levels. This suggests that oxidative stress may lead to decreased tumor growth and increased cell death in highly aggressive forms of prostate cancer."

Thymoquinone, found in black seed oil (Nigella sativa) has been shown to kill pancreatic cancer cells, colon cancer, and has been examined for its potential in the treatment of breast cancer. The new study demonstrated that Thymoquinone killed aggressive prostate cancer cells in lab studies and may prove to be an adjunctive therapy that can treat aggressive forms of prostate cancer.

Experimental Biology and Medicine

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Comments

where can I find thymoquinone
Hi there - It's in black cumin seeds that come from the nigella sativa plant.
i want to be a suppler if is not Impossible
I use this and it is very good. Black seed oil capsules make sure it is a pure one you are buying
Prophet Muhammed (saw) said this black seed cures all disease except death (aging). Muslims have known this for 1400 years.
When will there be human trials to determine efficacy and doses?
Mannstein, I don't know of any ongoing clinical trials. I see none registered when I search. Likely, there is not funding, unfortunately.
My understanding is that Black Seed oil contains gamma-linolenic acid, or "GLA," which can increase prostaglandin E production in your body. This may may affect blood pressure and inhibit blood clot formation, Is this correct or are thelevels of GLA so low that it's not a problem?
Mannstein - I really don't know! Fish oil, flax oil, aspirin and all can interfere with clotting and promote some bleeding and perhaps blood pressure could be an issue. With supplements that are not regulated, we wouldn't know. Thus, the need for good solid studies and safety warnings from results for natural compounds, right?
Thank you for answering my questions. I agree there need to be studies done.
I have prostrate cancer I am in my 60s how cn I take the black seed oil please specify the quantity to take either in the morning or night
I have it too, and I am informed that one takes 1 teaspoon of oil mixed with 1/2 a teaspoon of good honey (manuka honey) 30 mins before breakfast, ! teaspoon midday mixed with a freshly squeezed 1 orange, and 1 teaspoon of oil mixed with 1/2 teaspoon of honey again before bed. The honey acts as a carrier to help move the black seed oil into the cell where it can release its medical properties dark honey is best and Manuka honey is considered the queen of honeys.
Hi Mohamed. Until more studies are done there is not a way or specific dose that is known that you can take. The study was very preliminary but useful for future treatment. If you wish to add supplements, your doctor should know about that and give you good direction. I sincerely hope your treatment is a success. I am sorry you are facing this disease.