Disabling a protein frequently found in melanoma tumors may make the cancer more vulnerable to chemotherapy.
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Results from an adjuvant trial in high-risk melanoma patients demonstrated that a majority of patients treated with Leukine (sargramostim) achieved disease-free and/or overall survival. These findings, which indicate Leukine's potential in this cancer setting, were released at the 44th annual meeting of the American Society of Clinical Oncology (ASCO).
Results from the Phase II study (ASCO abstract #20027) show that 60 percent of the 45 high-risk patients enrolled in the trial experienced disease-free survival and 64 percent of patients achieved overall survival at 21 months.
In this study, Genasense was used to potentially enhance the clinical activity of temozolomide, the most commonly used anticancer drug for melanoma, combined with Abraxane.
Scientists are urging everyone to take safety measures against sun rays during this summer and to protect themselves from skin cancer.
deCODE scientists and academic colleagues from Europe and US expand upon the company's recent findings in the genetics of pigmentation traits in people of European descent, and demonstrate that certain of these common variants also confer risk of two types of skin cancer.
The point of entry for skin cancer in response to sun exposure is in receptor molecules, molecular "hooks" on the outer surface of cells that also pull cannabinoid compounds found in marijuana out of the bloodstream.
While occupational risks are inherent in many jobs, workers who make a living toiling in the sun face an increased threat of skin cancer from repeated overexposure to the sun's harmful ultraviolet (UV) rays.