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Vivus Presents Qnexa For Obesity Treatment

2008-12-14 07:56
Qnexa for obesity treatment

The new drug Qnexa for the treatment of obesity and weight loss shows promise. Qnexa is a proprietary therapeutic formulation and dosing regime that incorporates the active ingredients from two previously approved products with demonstrated weight loss properties. By combining the activity of each of these compounds, Qnexa simultaneously addresses appetite and satiety, the two main mechanisms that impact eating behavior. As such, Qnexa appears to induce significantly greater weight loss than either individual compound. Further, clinical trials conducted with Qnexa have demonstrated superior efficacy and a significantly improved adverse effect profile as compared to other therapeutic options.

VIVUS and Duke University conducted a 200-patient, double-blind, placebo controlled Phase 2 trial designed to examine the safety and efficacy of Qnexa. Findings from this study demonstrated:

* Qnexa achieved significantly greater weight loss as compared to placebo and each of the product's active ingredients alone
* Qnexa achieved a placebo-adjusted weight loss of 20.1 pounds at week 24
o This is nearly twice the weight loss achieved with a high dose of Sanofi-Aventis' Acomplia (rimonabant) at week 52 (10.6 pounds) in a similar group of patients
* Weight loss with Qnexa had not plateaued at 24 weeks as has been observed with other obesity therapeutics in development
* Only one patient dropped out of the Qnexa study arm due to side effects (2%) wih only 8% total non-completers for any reason. Dropouts for topiramate alone were 14%, phentermine alone 24%, and placebo 38%, indicating how well Qnexa was tolerated in this population.

VIVUS is currently undertaking additional formulation development for Qnexa to increase the convenience of patient dosing. Ultimately, the final Qnexa formulation will offer once-a-day, oral dosing utilizing advanced sustained and controlled release technology which will provide precision release of each active ingredient in order to maximize efficacy and tolerability.

OBESITY: THE FACTS

More than 30% of American adults (more than 60 million people) are obese

Obesity directly contributes to numerous life-threatening conditions: diabetes, cardiovascular disease, hypertension, stroke and cancer

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According to The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity, the cost of obesity in the U.S. in 2000 was more than $117 billion

With obesity at epidemic levels in the United States, there is a critical need for effective and safe therapeutics to assist individuals in losing weight and improving their overall health. To date, most obesity treatments on the market and currently in development have demonstrated limited efficacy and considerable side effects, creating a significant need in this important medical sector. In response to this need, VIVUS is advancing a proprietary obesity therapeutic, Qnexa™. In a recent clinical trial conducted at Duke University, Qnexa demonstrated nearly double the weight loss in less than half the time as compared to the leading obesity drug in development. Clinical data also indicates that Qnexa may potentially offer a significantly improved side effect profile as compared to other therapeutic options.

OBESITY: THE MARKET

The world wide obesity therapeutic market is currently estimated to be approximately $1 billion

Analysts estimate that the markets for new obesity therapeutics Acomplia and APD356 are also $1 billion

Analysts speculate that the total potential obesity drug market is between $5 billion and $10 billion annually

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Comments

Where can one buy Qnexa? Is Vivus already selling Qnexa? Also I would like to know if this obesity drug is over the counter or prescription only.
You can't buy it yet. Not approved for sale, Definitly by RX only.
Where can i buy this?
Will my insurnance pay for these pills???? I am Medicare supplement insurance with PPO and Part D drug program.
No, It will not be covered by any insurance. Its not available yet either.
Onexa is not available to purchase yet. Its presciption only when it does come out. It will NOT be covered by ANY health insurance. I work in research, we do clinical trails for the drug. It will be a while before its out. Its a very risky drug. Its Phentermine and Topamax combined. There are online pharmacies claiming they have a generic for it, its not true. The pharmacies are based in South America and not FDA approved, they can make any claim they want. You can currently get Phentermine by presciption now, which is the active "diet" ingredient in the pills.
If its fr two FDA approved meds, shouldn't it be approved quickly? Will it be available this year 2009?
Is there any new on the availability of Qnexa? So, ins won't cover it, eh? Any idea how much it will cost?
Based on the info I've read about Qnexa, it looks like a person can lose 1lbs. per week. So, how can that be bad for the rest of us who want to lose only 10lbs.?? My digestion is so screwed up, I can only digest semi properly meats, fruits & vegetables.... and sometimes my body has issues with that!! I thought how awesome it'd be to have Qnexa & not have to suffer as much as I do now!!
my doctor has just prescribed me both of these drugs indiviually. He said that they are seeing great results with people who are prescribed these drugs together. I need to lose about 20 lbs and he feels this will help me with the jump start I need. I am hoping it works.
Ok-2010 when will it be ready?
I actually participated in a clinical trial study for Qnexa and lost 69 pounds in a year. Im watching to see if they will be approved. I loved them.
I'm interested in speaking with you for a national news story. My email is mary.murray@nbcuni.com
How and where did you get it?
camc memorial division. Clinical trial. Charleston Wv
Please keep me posted on when or if Qnexa is approved by FDA or where it can be purchased.
When and how can I purc hase qnexa. How much does it cost and where can I buy it.
Please let me know when availabile...
Please let me know ASAP when Qnexa is avalible to purchase online!!!!!!
Would like to know when i can buy it also would like to know the price and side effects.
Let me know where and when I can buy Qnexa
Please notify me as soon as Quexa is available to purchase.
Please let me know when its available to buy.
Please Let me know as soon as this is available. I hope it is very soon. HELP
Please let me know when this is available to purchase
I'm researching Qnexa for a national TV news story and would like to speak to anyone who participated in any study of this medication. write me at mary.murray@nbcuni.com Thanks
I participated in the study of qnexa. I lost 69 lbs in 1 yr. Feel free to email me.
where can i buy qnexa
you can't yet, its waiting approval from the fda
Tell me more about the free trial.

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